Generic Name: Domperidone Maleate 5mg/ml
Manufacturer/Distributor: The ACME Laboratories Ltd.
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Indications of Don-A 15
Pharmacology
Domperidone may be a dopamine antagonist that primarily targets the stomach's and the Chemoreceptor Trigger Zone's (CTZ) dopamine receptors. Its gastroprokinetic activity is based on the dopamine receptors it blocks, which affect gastrointestinal tract motility. Domperidone has almost no effect on the dopaminergic receptors in the brain because of its flimsy passage through the blood-brain barrier, thereby avoiding psychotropic and neurologic side effects. Domperidone improves antral and duodenal peristalsis, restores normal upper gastrointestinal tract motility and tone, and directs pylorus withdrawal. It also promotes gastric purging. Additionally, domperidone increases esophageal peristalsis and decreases the weight of the esophageal sphincter, preventing the release of gastric contents.
Dosage & Administration
Domperidone should be taken if necessary before going to bed and 15–30 minutes before meals.
The typical Domperidone oral dosage is as follows:
Distension of the stomach:
In conditions that are acute or subacute (primarily acute nausea and vomiting):
Using suppositories, by rectum
Twelve weeks is the maximum treatment
Interaction of Don-A 15ml
Domperidone may lessen the hypoprolactemic effects of bromocriptine. Domperidone's influence on Gl function may be countered by antimuscarinics and opiate analgesics. Exercise caution when combining domperidone with MAO (monoamine oxidase)
Contraindications
Domperidone is not recommended for patients who have a known hypersensitivity to the medicine or for neonates. When gastrointestinal stimulation is potentially harmful, such as gastrointestinal hemorrhage, mechanical obstruction, or perforation, do not use domperidone. Patients with a prolactin-releasing pituitary tumor are also advised against taking it (prolactinoma).
Side Effects of Don-A 15ml
Since young children's blood-brain barriers have not yet fully developed, there is a high risk of extrapyramidal effects when using domperidone on them. Domperidone is highly metabolized in the liver, so patients with hepatic impairment should use it with caution.
Pregnancy & Lactation
Because the safety of domperidone has not been established, it is not recommended for use during pregnancy. The teratogenic effect on the fetus has not been shown in animal research. Domperidone can help with galactorrhea and postpartum lactation. It's secreted in breast milk, but in such small amounts that it's not considered dangerous.
Precautions & Warnings
Domperidone should be used with extreme caution in children due to an elevated risk of extrapyramidal effects due to an incompletely established blood-brain barrier in young children. Domperidone should be taken with caution in patients with a hepatic impairment since it is highly metabolized in the liver.
Storage Conditions
Store below 30°C, Protected from light & moisture. Keep out of children's reach.
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